Spot On

(36 results)
Frontline Plus Cat Flea & Tick Treatment
3 sizes
(546)
$39.99 - $98.99
Save 40% on your first Autoship order!
Buy 1 Get 2nd 25% off All Flea & Tick
+ 3 more
Advantage® II Over 9 lbs Cat Flea Prevention & Treatment
4 sizes
(691)
$16.99 - $68.99
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+ 3 more
Advantage® II 5-9 lbs Cat Flea Prevention & Treatment
4 sizes
(386)
$16.99 - $70.99
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+ 3 more
Advantage® II 2-5 lbs Kitten Flea Prevention & Treatment
(54)
$33.59
$34.99
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+ 3 more
Advantage Topical Cat Flea Treatment and Prevention For Small Cats 2-9 lbs.
(1)
$14.99
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+ 3 more
Revolution Plus for Cats 11.1-22 lbs Green - 3 or 6 Month Supply
2 sizes
(18)
$91.09 - $159.29
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Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 1 more
Revolution Plus for Cats 5.6-11 lbs Orange - 3 or 6 Month Supply
2 sizes
(13)
$85.79 - $154.49
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+ 1 more
Cheristin, Cat Flea and Tick Treatment and Prevention
3 sizes
(1)
$16.69 - $78.69
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Buy 1 Get 2nd 25% off All Flea & Tick
+ 1 more
PetArmor® Plus for Cats Over 1.5 lbs Flea & Tick Spot On Treatment
2 sizes
(1003)
$24.99 - $39.99
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Buy 1 Get 2nd 25% off All Flea & Tick
+ 3 more
Advantage® XD Over 9 lbs Large Cat Flea Prevention & Treatment
3 sizes
(744)
$35.99 - $98.99
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+ 3 more
NextStar® Flea & Tick Prevention for Cats
2 sizes
(172)
$34.99 - $52.99
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+ 1 more
Advantage Topical Cat Flea Treatment and Prevention For Large Cats Over 9 lbs.
(1)
$14.99
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+ 3 more
Advantage® XD 1.8-9 lbs Small Cat Flea Prevention & Treatment
3 sizes
(611)
$35.99 - $98.99
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+ 3 more
Bravecto Topical Solution for Cats, 6.2 - 13.8 lbs 250 mg Blue
(5)
$72.99
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Bravecto Plus Topical Solution for Cats
(1)
$51.99 - $52.99
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Advantage Multi for Cats 9.1-18 lbs
2 sizes
(1)
$19.99 - $119.80
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+ 1 more
Revolution Topical for Cats 5.1-15 lbs Blue
3 sizes
(2)
$104.49 - $378.99
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+ 1 more
Only Natural Pet Flea & Tick Spot On 3 count
(1)
$19.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
Senergy (selamectin) Topical for Cats 5.1 - 15 lbs, 3 doses
(1)
$49.39
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+ 1 more
Selarid (selamectin) Topical for Cats 5.1-15 lbs, Blue (6 Month Supply)
(0)
$71.99
$92.59
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+ 1 more
Bravecto Topical Solution for Cats, 13.8 - 27.5 lbs 500 mg Purple
(1)
$73.99
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Only Natural Pet® Cat Flea, Tick & Mosquito Treatment
(443)
$19.99
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+ 3 more
Liquid-Vet® Feline Flea & Tick+Support Formula
(0)
$11.49
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+ 2 more
Vetality Naturals Flea & Tick Topicals for Cats
(7)
$12.89
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+ 2 more
Senergy (selamectin) Topical for Cats 15.1 - 22 lbs, 3 doses
(0)
$50.59
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+ 1 more
Senergy (selamectin) Topical for Kittens and Puppies Up to 5 lbs, 3 doses
(0)
$42.89
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+ 1 more
Selarid (selamectin) Topical for Cats 15.1-22 lbs, Taupe (6 Month Supply)
(0)
$73.49
$94.79
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+ 1 more
Selarid (selamectin) Topical for Kittens/Puppies Up to 5 lbs, Mauve (3 Month Supply)
(0)
$32.49
$43.59
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+ 1 more
Advantage Multi for Cats 5.1-9 lbs
2 sizes
(2)
$19.79 - $118.69
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+ 1 more
Revolution Topical for Cats 15.1-22 lbs Taupe
3 sizes
(1)
$112.79 - $388.99
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+ 1 more
Revolution Topical for Puppies and Kittens up to 5 lbs Pink
(0)
$71.99
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Sign In & Enjoy Free Shipping Over $49
Revolution Plus for Cats 2.8-5.5 lbs Gold - 3 or 6 Month Supply
2 sizes
(0)
$70.29 - $135.79
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
Save 35% On Your First Autoship Order!
+ 1 more
Bravecto Topical Solution for Cats, 2.6 - 6.2 lbs 112.5 mg Green
(0)
$71.99
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Advantage Multi for Cats 2-5 lbs, 3 Month Supply
(0)
$74.29
Save 40% on your first Autoship order!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 1 more
Revolution Topical for Puppies and Kittens up to 5 lbs Pink - 3 Month or 6 Month Supply
(0)
$71.39
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Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 1 more
Sergeant's Guardian Flea and Tick Topical for Cats - 6lbs and over - 3 Month Supply
(4)
$5.19
$9.99
Save 40% on your first Autoship order!
Buy 1 Get 2nd 25% off All Flea & Tick
+ 2 more
  1. 1
Fleas and ticks are absolutely no fun for you or your pet cat. They can cause issues for your pet when not addressed. If your cat has fleas or ticks, you should talk to your vet about the best options to help get rid of them. Pet parents can find a great selection of cat flea topical drops and cat flea spot-ons at PetSmart. We want to help you protect your cat from fleas and ticks. 
Our selection of cat flea/tick prevention products extends far past only flea and tick topical drops for cats. We also carry: 
You are sure to find what you need to help get rid of fleas or protect your cats from them at PetSmart. Need other cat supplies while you’re here? We have you covered. 
PetSmart also offers convenient shopping with curbside or in-store pickup. Need something today? We have select items available for same-day delivery in most areas powered by DoorDash. For items you purchase frequently, PetSmart has Autoship that automatically delivers the items you want to your door as often as you’d like. Check the website to see which items are eligible.