Spot Ons

(57 results)
K9 Advantix® II Over 55 lbs Dog Flea & Tick Treatment
4 sizes
(310)
$18.99 - $79.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Frontline Plus Flea & Tick Dog Treatment 5-22 lbs
3 sizes
(554)
$39.99 - $98.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Frontline Plus Flea & Tick Dog Treatment 45-88 lbs
3 sizes
(611)
$39.99 - $96.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
K9 Advantix® II 21-55 lbs Dog Flea & Tick Treatment
4 sizes
(271)
$18.99 - $79.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
K9 Advantix® II 11-20 lbs Dog Flea & Tick Treatment
4 sizes
(270)
$18.99 - $79.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Frontline Plus Flea and Tick Dog Treatment 23-44 lbs
3 sizes
(367)
$39.99 - $96.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Frontline Plus Flea & Tick Dog Treatment 89-132 lbs
3 sizes
(506)
$39.99 - $96.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
K9 Advantix® II Under 10 lbs Dog Flea & Tick Treatment
4 sizes
(245)
$18.99 - $79.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Dogs 41-80 Lbs
2 sizes
(948)
$49.99 - $89.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Dogs 11-20 Lbs
2 sizes
(923)
$49.99 - $89.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
PetArmor® Plus for Dogs 45-88 lbs Flea & Tick Spot On Treatment
2 sizes
(1862)
$26.99 - $39.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
PetArmor® Plus for Dogs 5-22lbs Flea & Tick Spot On Treatment
2 sizes
(1910)
$26.99 - $39.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Advantage® II 21-55 lbs Dog Flea & Lice Treatment
2 sizes
(60)
$51.99 - $68.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Advantage® II Over 55 lbs Dog Flea & Lice Treatment
2 sizes
(69)
$51.99 - $68.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Advantage Multi Topical for Dogs 55.1-88 lbs Blue
2 sizes
(1)
$21.79 - $130.39
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Dogs 81-120 Lbs
2 sizes
(922)
$49.99 - $89.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
Advantage® II 11-20 lbs Dog Flea & Lice Treatment
2 sizes
(57)
$51.99 - $68.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
NextStar® Flea & Tick Prevention for Small Dogs 5-22 lbs
2 sizes
(382)
$34.99 - $52.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
K9 Advantix® Classic 21-55 lbs Dog Flea & Tick Treatment
(1)
$14.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
NextStar® Flea & Tick Prevention for Large Dogs 45-88 lbs
2 sizes
(1203)
$35.99 - $52.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
Advantage Multi Topical for Dogs 20.1-55 lbs Red
2 sizes
(1)
$21.69 - $129.79
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Revolution Topical for Dogs 40.1-85 Teal - 3 Month or 6 Month Supply
2 sizes
(1)
$97.19 - $175.49
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Revolution Topical for Dogs 10.1-20 Brown - 3 Month or 6 Month Supply
2 sizes
(3)
$94.49 - $166.39
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Dogs 5-10 Lbs
2 sizes
(922)
$49.99 - $89.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Dogs 21-40 Lbs
2 sizes
(922)
$49.99 - $89.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
PetArmor® Plus for Dogs 23-44 lbs Flea & Tick Spot On Treatment
2 sizes
(1849)
$26.99 - $39.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Advantage® II 3-10 lbs Dog Flea & Lice Treatment
2 sizes
(68)
$51.99 - $68.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
PetArmor® Ear Mite & Tick Treatment
(57)
$5.49
$8.29
Extra 20% off online only with code SAVE20, see terms
Save 35% On Your First Autoship Order!
+ 3 more
NextStar® Flea & Tick Prevention for Medium Dogs 23-44 lbs
2 sizes
(1201)
$34.99 - $52.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
K9 Advantix® Classic 55+ lbs Dog Flea & Tick Treatment
(1)
$14.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Selarid (selamectin) Topical for Dogs 40.1-85 lbs Teal, 6 Month Supply
(0)
$73.49
$94.49
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Advantage Multi Topical for Dogs 9.1-20 lbs Teal
2 sizes
(5)
$21.49 - $128.49
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Revolution Topical for Dogs 20.1-40 Red  - 3 Month or 6 Month Supply
2 sizes
(1)
$96.19 - $175.49
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Advantage Multi Topical for Dogs 88.1-110 lbs Brown
2 sizes
(5)
$21.89 - $130.99
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Advantage Multi Topical for Dogs 3-9 lbs Green
2 sizes
(5)
$21.39 - $127.89
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
Revolution Topical for Dogs 5.1-10 Purple - 3 Month or 6 Month Supply
2 sizes
(0)
$91.29 - $161.99
Save an additional 20% on your 1st Pharmacy Autoship Order with code SAVE20RX!
Spend $100 on Pharmacy, Save $20 on your Order! (exclusions apply)
+ 3 more
PetArmor® Plus for Dogs 89-132 lbs Flea & Tick Spot On Treatment
2 sizes
(1821)
$26.99 - $39.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
Only Natural Pet® EasyDefense™ Herbal Dog Flea, Tick & Mosquito Treatment
3 sizes
(617)
$19.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 4 more
NextStar® Flea & Tick Prevention for Extra-Large Dogs 89-132 lbs
2 sizes
(1369)
$34.99 - $52.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 2 more
Sergeant's Guardian Flea & Tick Topical for Dogs 7-32 lbs
(0)
$5.99
Buy 1 Get 2nd 25% off All Flea & Tick
2X points (4% back in savings) on all Flea & Tick purchases
+ 3 more
  1. 1
  2. 2
Fleas are no fun for your dog or for you. They can cause issues for your pet when not addressed. If your dog has fleas or ticks, you should talk to your vet about the best options to help get rid of them. Pet parents looking for dog flea spot-ons or topical flea treatments for dogs can find what they need at PetSmart. We want to help you give your dog the best care with the best products. 
 
Our selection of dog flea prevention products includes options like: 
 
You can find everything you need to care for your pup at PetSmart. Need other dog supplies while you’re here? We have you covered. 
 
PetSmart also offers convenient shopping with curbside or in-store pickup. Need something today? We have select items available for same-day delivery in most areas powered by DoorDash. For items you purchase frequently, PetSmart has Autoship that automatically delivers the items you want to your door as often as you’d like. Check the website to see which items are eligible.