Spot Ons

(58 results)
Frontline Plus Flea & Tick Spot Treatment for Small Dogs, 5-22 lbs
3 sizes
(564)
$40.98 - $98.98
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® II Flea & Tick Prevention for Extra Large Dogs over 55 lbs, Monthly Spot Treatment
4 sizes
(320)
$19.99 - $79.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® II Flea & Tick Prevention for Large Dogs 21-55 lbs, Monthly Spot Treatment
4 sizes
(277)
$19.99 - $79.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Frontline Plus Flea & Tick Spot Treatment for Large Dogs, 45-88 lbs
3 sizes
(624)
$40.98 - $98.98
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® II Flea & Tick Prevention for Medium Dogs 11-20 lbs, Monthly Spot Treatment
4 sizes
(277)
$19.99 - $79.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Frontline Plus Flea & Tick Spot Treatment for Medium Dogs, 23-44 lbs
3 sizes
(373)
$40.98 - $98.98
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® Flea, Tick & Mosquito Prevention for Extra Large Dogs 55+ lbs, Monthly Dose Treatment
(147)
$14.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® Flea, Tick & Mosquito Prevention for Large Dogs 21-55 lbs, Monthly Dose Treatment
(202)
$14.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Advantage® II Flea Prevention & Treatment for Extra Large Dogs over 55 lbs, Monthly Doses
2 sizes
(82)
$50.99 - $66.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® Flea, Tick & Mosquito Prevention for Medium Dogs 11-20 lbs, Monthly Dose Treatment
(132)
$14.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® Flea, Tick & Mosquito Prevention for Small Dogs 4-10 lbs, Monthly Dose Treatment
(101)
$14.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Advantage Multi Dog 6-in-1 Heartworm Prevention | Kills Fleas | Dogs 20.1-55 lbs. | 6-Month Supply
2 sizes
(1)
$21.82 - $141.79
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Advantage Multi Dog 6-in-1 Heartworm Prevention | Kills Fleas | Dogs 9.1-20 lbs. | 6-Month Supply
2 sizes
(5)
$21.82 - $141.79
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Revolution Topical for Dogs 10.1-20 Brown - 3 Month or 6 Month Supply
2 sizes
(3)
$103.93 - $182.92
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Large Dogs, 41-80 lbs
2 sizes
(951)
$52.48 - $94.48
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Frontline Plus Flea & Tick Spot Treatment for X-Large Dogs, 89-132 lbs
3 sizes
(516)
$40.98 - $98.98
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
PetArmor® Plus Flea & Tick Prevention for Large Dogs, 45-88 lbs, Spot On Treatment
2 sizes
(1870)
$26.19 - $42.27
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
PetArmor® Plus Flea & Tick Prevention for Small Dogs, 5-22 lbs, Spot On Treatment
2 sizes
(1918)
$26.19 - $42.27
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Advantage® II Flea Prevention & Treatment for Large Dogs 21-55 lbs, Monthly Doses
2 sizes
(60)
$50.99 - $66.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
K9 Advantix® II Flea & Tick Prevention for Small Dogs 4-10 lbs, Monthly Spot Treatment
4 sizes
(259)
$19.99 - $79.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
NextStar® Flea & Tick Waterproof Topical Prevention for Medium Dogs, 23-44 lbs
2 sizes
(1204)
$34.99 - $52.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
NextStar® Flea & Tick Waterproof Topical Prevention for Large Dogs, 45-88 lbs
2 sizes
(1205)
$34.99 - $52.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
NextStar® Flea & Tick Waterproof Topical Prevention for Small Dogs, 5-22 lbs
2 sizes
(384)
$34.99 - $52.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Revolution Topical for Dogs 40.1-85 Teal - 3 Month or 6 Month Supply
2 sizes
(2)
$106.88 - $193.07
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Revolution Topical for Dogs 20.1-40 Red  - 3 Month or 6 Month Supply
2 sizes
(1)
$105.73 - $193.05
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Advantage Multi Dog 6-in-1 Heartworm Prevention | Kills Fleas | Dogs 55.1-88 lbs. | 6-Month Supply
2 sizes
(2)
$21.82 - $141.79
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Advantage Multi Dog 6-in-1 Heartworm Prevention | Kills Fleas | Dogs 3-9 lbs. | 6-Month Supply
2 sizes
(5)
$21.82 - $141.79
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Revolution Topical for Dogs 85.1-130 Plum - 3 Month or 6 Month Supply
2 sizes
(0)
$134.85 - $246.50
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Revolution Topical for Puppies and Kittens up to 5 lbs Pink - 3 Month Supply
(0)
$76.30
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Revolution Topical for Dogs 5.1-10 Purple - 3 Month or 6 Month Supply
2 sizes
(0)
$100.33 - $178.20
Save 40% on your first Prescription Flea and Tick Autoship order!
Sign In & Enjoy Free Shipping Over $49
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Small Dogs, 11-20 lbs
2 sizes
(923)
$52.48 - $94.48
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for Medium Dogs, 21-40 lbs
2 sizes
(924)
$52.48 - $94.48
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for X-Small Dogs, 5-10 lbs
2 sizes
(923)
$52.48 - $94.48
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Frontline Shield Extra Strength Flea & Tick Spot Treatment for X-Large Dogs, 81-120 lbs
2 sizes
(922)
$52.48 - $94.48
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
PetArmor® Plus Flea & Tick Prevention for Medium Dogs, 23-44 lbs, Spot On Treatment
2 sizes
(1857)
$26.19 - $42.27
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Advantage® II Flea Prevention & Treatment for Small Dogs 3-10 lbs, Monthly Doses
2 sizes
(72)
$50.99 - $66.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Advantage® II Flea Prevention & Treatment for Medium Dogs 11-20 lbs, Monthly Doses
2 sizes
(57)
$50.99 - $66.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
NextStar® Flea & Tick Waterproof Topical Prevention for X-Large Dogs, 89-132 lbs
2 sizes
(1373)
$34.99 - $52.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 2 more
Sergeant's Guardian Flea & Tick Topical for Dogs 7-32 lbs
(0)
$5.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 1 more
Sergeant's Guardian Flea & Tick Topical for Dogs 33-66 lbs
(0)
$5.99
Buy 1, get the 2nd 25% OFF ALL flea & tick products
Save 40% Off First Autoship Order on Flea and Tick Products
+ 1 more
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Fleas are no fun for your dog or for you. They can cause issues for your pet when not addressed. If your dog has fleas or ticks, you should talk to your vet about the best options to help get rid of them. Pet parents looking for dog flea spot-ons or topical flea treatments for dogs can find what they need at PetSmart. We want to help you give your dog the best care with the best products. 
 
Our selection of dog flea prevention products includes options like: 
 
You can find everything you need to care for your pup at PetSmart. Need other dog supplies while you’re here? We have you covered. 
 
PetSmart also offers convenient shopping with curbside or in-store pickup. Need something today? We have select items available for same-day delivery in most areas powered by DoorDash. For items you purchase frequently, PetSmart has Autoship that automatically delivers the items you want to your door as often as you’d like. Check the website to see which items are eligible.