Spot On

(38 results)
Advantage® II Flea Prevention & Treatment for Large Cats over 9 lbs, Monthly Doses
3 sizes
(895)
$33.59 - $69.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Frontline Plus Flea & Tick Spot Treatment for Cats, 1.5 lbs and over
3 sizes
(578)
$37.12 - $98.98
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Advantage® II Flea Prevention & Treatment for Small Cats 5-9 lbs, Monthly Doses
4 sizes
(495)
$19.99 - $69.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
PetArmor® Plus Flea & Tick Prevention for Cats over 1.5 lbs, Spot On Treatment
2 sizes
(1024)
$26.14 - $39.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 4 more
Advantage Topical Flea Treatment and Prevention for Large Cats Over 9 lbs, 2 monthly doses
(298)
$14.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Advantage® II Flea Prevention & Treatment for Cats and Kittens 2-5 lbs, Monthly Doses
(58)
$33.59
$34.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Advantage Topical Flea Treatment and Prevention for Small Cats 2-9 lbs, 2 monthly doses
(200)
$14.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Revolution Plus for Cats 5.6-11 lbs Orange - 3 or 6 Month Supply
2 sizes
(16)
$91.74 - $165.24
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Revolution Plus for Cats 11.1-22 lbs Green - 3 or 6 Month Supply
2 sizes
(21)
$97.38 - $170.34
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Cheristin, Cat Flea and Tick Treatment and Prevention
3 sizes
(43)
$17.99 - $84.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 35% On Your First Autoship Order!
+ 1 more
Advantage® XD Flea Prevention & Treatment for Large Cats over 9 lbs, 2 Months Protection per Dose
3 sizes
(754)
$37.99 - $99.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
NextStar® Flea & Tick Waterproof Topical Prevention for Cats over 3.5 lbs
2 sizes
(181)
$34.99 - $52.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Advantage® XD Flea Prevention & Treatment for Small Cats 1.8-9 lbs, 2 Months Protection per Dose
3 sizes
(617)
$37.99 - $99.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Bravecto Topical Solution for Cats, 6.2 - 13.8 lbs 250 mg Blue
(5)
$76.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Sign In & Enjoy Free Shipping Over $49
Advantage Multi Topical Solution for Cats, 9.1-18 lbs, 1 or 6 Month Supply
2 sizes
(1)
$19.97 - $129.79
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Bravecto Plus Topical Solution for Cats, 6.2-13.8 lb (Blue), 1 Dose,  2-Month Supply
(0)
$56.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Sign In & Enjoy Free Shipping Over $49
Selarid (selamectin) Topical for Cats 5.1-15 lbs, Blue (6 Month Supply)
(0)
$71.91
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Revolution Topical for Puppies and Kittens up to 5 lbs Pink - 3 Month Supply
(0)
$76.99
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Revolution Topical for Cats 5.1-15 lbs Blue
3 sizes
(2)
$114.97 - $419.99
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Only Natural Pet® EasyDefense™ Flea &Tick Squeeze-On Treatment for Cats, 3 count
(155)
$19.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
Vet's Best Flea & Tick Cat Waterless Bath - Natural Spot Treatment - Cotton Spice Scent - 5 FL OZ
(2)
$15.01
$16.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 2 more
Senergy (selamectin) Topical for Cats 5.1 - 15 lbs, 3 doses
(1)
$49.34
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Bravecto Topical Solution for Cats, 13.8 - 27.5 lbs 500 mg Purple
(1)
$78.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Sign In & Enjoy Free Shipping Over $49
Liquid-Vet® Feline Flea & Tick+Support Formula
(0)
$11.49
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 35% On Your First Autoship Order!
+ 1 more
Vetality Naturals Flea & Tick Topicals for Cats
(7)
$11.97
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 35% On Your First Autoship Order!
+ 1 more
Senergy (selamectin) Topical for Cats 15.1 - 22 lbs, 3 doses
(0)
$50.59
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Senergy (selamectin) Topical for Kittens and Puppies Up to 5 lbs, 3 doses
(0)
$42.83
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Bravecto Plus Topical Solution for Cats, 13.8-27.5 lb (Purple), 1 Dose,  2-Month Supply
(0)
$56.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Sign In & Enjoy Free Shipping Over $49
Bravecto Plus Topical Solution for Cats, 2.6-6.2 lb (Green), 1 Dose, 2-Month Supply
(2)
$54.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Sign In & Enjoy Free Shipping Over $49
Selarid (selamectin) Topical for Cats 15.1-22 lbs, Taupe (6 Month Supply)
(0)
$73.49
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Selarid (selamectin) Topical for Kittens/Puppies Up to 5 lbs, Mauve (3 Month Supply)
(0)
$32.49
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Advantage Multi Topical Solution for Cats, 5.1-9 lbs, 1 or 6 Month Supply
2 sizes
(2)
$19.78 - $128.59
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Revolution Topical for Cats 15.1-22 lbs Taupe
3 sizes
(1)
$124.99 - $429.99
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Revolution Plus for Cats 2.8-5.5 lbs Gold - 3 or 6 Month Supply
2 sizes
(0)
$75.18 - $145.25
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Bravecto Topical Solution for Cats, 2.6 - 6.2 lbs 112.5 mg Green
(0)
$76.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Sign In & Enjoy Free Shipping Over $49
Advantage Multi Topical Solution for Cats, 2-5 lbs, 3 Month Supply
(1)
$80.49
Save $20 when you spend $100+ on prescriptions thru 7/5
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
+ 2 more
Sergeant's Guardian Flea and Tick Topical for Cats - 6lbs and over - 3 Month Supply
(8)
$5.99
$9.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 35% On Your First Autoship Order!
+ 1 more
Only Natural Pet® EasyDefense™ Flea & Tick Spray, 8oz
(154)
$10.99
$11.99
10X points (20% back in savings) on ALL flea & tick products including prescriptions.
Save 15% when you spend $50+ on FREE Same-Day Delivery
+ 3 more
  1. 1
Fleas and ticks are absolutely no fun for you or your pet cat. They can cause issues for your pet when not addressed. If your cat has fleas or ticks, you should talk to your vet about the best options to help get rid of them. Pet parents can find a great selection of cat flea topical drops and cat flea spot-ons at PetSmart. We want to help you protect your cat from fleas and ticks. 
Our selection of cat flea/tick prevention products extends far past only flea and tick topical drops for cats. We also carry: 
You are sure to find what you need to help get rid of fleas or protect your cats from them at PetSmart. Need other cat supplies while you’re here? We have you covered. 
PetSmart also offers convenient shopping with curbside or in-store pickup. Need something today? We have select items available for same-day delivery in most areas powered by DoorDash. For items you purchase frequently, PetSmart has Autoship that automatically delivers the items you want to your door as often as you’d like. Check the website to see which items are eligible.