Description:

Simparica Trio is a pork liver–flavored chewable tablet administered once per month to protect your dog from heartworm disease, fleas, ticks, roundworms, and hookworms.

Please note: Due to a manufacturer redesign, the same trusted formulation is receiving new, easier–to–read packaging. Your medication may arrive with this updated packaging, depending on manufacturer availability.

Simparica Trio is the first FDA–approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.

Studies to support FDA–approval showed one dose provided 100% protection against heartworm disease.

Simparica Trio is the first FDA–approved product of its kind and the only one approved to prevent Lyme infections as a direct result of killing deer ticks. It's proven to kill five types of ticks including theGulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick.

Prevents flea infestation by killing fleas before they can even lay eggs. Starts killing within 4 hours and achieved 100% effectiveness in 8 hours in a study. Treats roundworms and hookworms to protect your dog from intestinal parasites.

Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month with or without food. In a study 9 out of 10 dogs voluntarily consumed this tasty liver–flavored chew.1

Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) is the first FDA–approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds, Simparica Trio begins working against fleas in just four hours and kills five types of ticks – including the deer tick that may cause Lyme disease. Just one tasty liver–flavored chew does the job of two or three parasite medications, and in a study nine out of 10 dogs ate Simparica Trio voluntarily.1It can be given with or without food. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn't providing sufficient protection, please call Zoetis' medical support team to discuss the satisfaction guarantee at 1–888–ZOETIS1. Trust the #1 heartworm disease preventative chosen by veterinarians2and prescribed to over 7 million patients.3Available by veterinarian prescription only. Ask your vet if Simparica Trio is right for your dog.

References:

1. Study A161C–US–15–634. Data on file. Zoetis Inc.

2. Heartworm Disease Preventative; DVM 360 '22 Survey.

3. Kynetec Purchasing Data Vet Clinics Q3 QBR

Product sourced directly from the manufacturer or their approved distributor. Guaranteed genuine product backed by the manufacturer.

For: Dogs (8 weeks of age and older)

Drug Class: Isoxazoline ectoparasiticide, Macrocyclic lactone antiparasitic, Tetrahydropyrimidine anthelmintic

Product Strength & Size: Weight RangeSarolaner (per tablet)Moxidectin (per tablet)Pyrantel (per tablet)2.8 to 5.5 lbs3 mg0.06 mg12.5 mg5.6 to 11 lbs6 mg0.12 mg25 mg11.1 to 22 lbs12 mg0.24 mg50 mg22.1 to 44 lbs24 mg0.48 mg100 mg44.1 to 88 lbs48 mg0.96 mg200 mg88.1 to 132 lbs72 mg1.44 mg300 mg*For dogs over 132 lbs, administer the appropriate combination of tablets to cover your pet's body weight.Usage*For complete product information, please review the full prescribing information in the manufacturer package insert.Simparica Trio should be given orally at monthly intervals year–round, or as otherwise directed by your veterinarian.Do NOT remove tablets from the foil blister pack until just before administration. The sealed blister pack should be kept in its original box⁄packaging for protection from environmental factors (e.g., light, moisture).Manufacturer Dosage and Administration:Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg⁄lb (1.2 mg⁄kg) sarolaner, 0.011 mg⁄lb (24 Î¼g⁄kg) moxidectin, and 2.27 mg⁄lb (5 mg⁄kg) pyrantel (as pamoate salt).Simparica Trio can be offered to the dog with or without food.Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.Missed dosesIf a dose is missed: give Simparica Trio immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.StorageStore in a cool, dry place at a controlled room temperature (at or below 86°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time ofdosing. Store away from heat and direct sunlight.Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsSimparica Trio is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, and lowered energy level.Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete product information including warnings and precautions, please refer to the manufacturer package insert.For oral use in dogs only– not for use in humans.Sarolaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adultD. immitis.The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.Do not administer to animals with a known history or suspected allergy⁄hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure toinform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.Drug and food interactionsThere are no documented drug or food interactions with Simparica Trio.*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse

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Simparica Trio Chewable Tablets for Dogs - 44.1-88 lbs, Green Box

Simparica Trio Chewable Tablets for Dogs - 22.1-44 lbs, Blue Box

Simparica Trio Chewable Tablets for Dogs - 11.1-22 lbs, Caramel Box

Simparica Trio Chewable Tablets for Dogs - 88.1-132 lbs, Brown Box

Simparica Trio Chewable Tablets for Dogs - 5.6-11 lbs, Purple Box

Simparica Trio Chewable Tablets for Dogs - 11.1-22 lbs, Caramel Box

Simparica Trio Chewable Tablets for Dogs - 2.8-5.5 lbs, Gold Box