Cardalis Chewable Tablets for Dogs - 40mg/5mg, 30 Tablets
- Quantity:
- 30 Count
About this item
Cardalis (Spironolactone and Benazepril Hydrochloride) is indicated with concurrent therapy (e.g. furosemide, etc.) for the management of clinical signs of mild, moderate, or severe congestive heart failure in dogs due to atrioventricular valvular insufficiency (AVVI). Cardalis is the only FDA approved combination drug for the management of congestive heart failure in dogs. Cardalis for dogs contains two active ingredients, spironolactone and benazepril hydrochloride, in a fixed ratio of 8:1 respectively.
Key Benefits:
Formulated For: Dogs
Why Use It: FDA approved combination drug for the management of congestive heart failure in dogs. Easy to administer chewable tablets. Available in various strengths.
Health Consideration: Congestive heart failure in dogs
How is Medication Given? Use as directed by your Veterinarian. Cardalis administration should begin after pulmonary edema is stabilized. Cardalis should be administered orally oncedaily at a dose of 0.9 mg/lb (2 mg/kg) spironolactone and 0.11 mg/lb (0.25 mg/kg) benazepril hydrochloride, according to dog body weight using asuitable combination of whole and/or half tablets. All tablet strengths are scored and the calculated dosage according to dogs weight should be to thenearest half-tablet increment. Cardalis should be administered with food.
What Results Can I Expect? Mechanism of Action: The main pharmacological target of spironolactone and benazepril is the renin-angiotensin-aldosterone system (RAAS) at different levels in the cascade. Spironolactone and its active metabolites (including 7--thiomethyl-spironolactone and canrenone) act as specific antagonists of aldosterone (regardless of the source) by binding competitively to mineralocorticoid receptors located in the kidneys, heart and blood vessels. Benazepril hydrochloride is a prodrug hydrolyzed in vivo into its active metabolite, benazeprilat. Benazeprilat is a highly potent and selective inhibitor of angiotensin-converting enzyme (ACE), thus preventing the conversion of inactive angiotensin I to active angiotensin II. This prevents deleterious effects of vasoconstriction and aldosterone release, including sodium and water retention, and vascular and myocardial remodeling. However, aldosterone release is not fully controlled by ACE inhibitors because angiotensin II is also produced by non-ACE pathways. Therefore, concomitant use of the aldosterone antagonist spironolactone and the ACE inhibitor benazepril hydrochloride inhibits both ACE and non-ACE pathways.
What Form Does Medication Come In? 20 mg / 2.5 mg , 40mg/5mg, 80mg/10mg
Manufacturer: Ceva
Common Brand Name: Cardalis
Dose and Administration: Use as directed by your Veterinarian. Cardalis administration should begin after pulmonary edema is stabilized. Cardalis should be administered orally oncedaily at a dose of 0.9 mg/lb (2 mg/kg) spironolactone and 0.11 mg/lb (0.25 mg/kg) benazepril hydrochloride, according to dog body weight using asuitable combination of whole and/or half tablets. All tablet strengths are scored and the calculated dosage according to dogs weight should be to thenearest half-tablet increment. Cardalis should be administered with food.
Possible Side Effects: The following adverse events were seen in fewer than 5% of the study animals, in decreasing order: urine abnormalities, uid in abdomen, ataxia, weight loss, digestive tract disorder, hypertension, electrolyte disorder, bronchitis, and hyperactivity. Renal insuficiency was reported more frequently in dogs treated withCARDALIS. This finding may be also attributed to the concurrent administration of furosemide. The incidence of death, including euthanasia and sudden death, was similar in dogs treated with CARDALIS or benazepril hydrochloride. In most cases, death was attributable to the progression of heart disease or the clinical signs associated with congestive heart failure. Deaths of unknown cause were presumed to be cardiac in nature.
Precautions Keep away from children and animals. Contraindications : Do not administer CARDALIS in conjunction with non-steroidal anti-inflammatory drugs (NSAIDs) in dogs with renal insuficiency. Do not administer CARDALIS to dogs with hypoadrenocorticism (Addisons Disease), hyperkalemia, or hyponatremia. Do not administer CARDALIS to animals with known hypersensitivity to ACE inhibitors or spironolactone.
Storage Recommendations: Store at room temp 4 degrees C (39 degrees F) and 25 degrees C (77 degrees F), avoiding excess heat or cold.
In Case of Overdose: Contact your nearest emergency animal hospital.
Is Prescription from a Vet Required? Yes
From the manufacturer
