DESCRIPTION: Sileo Gel for Dogs contains the active ingredient Dexmedetomidine. This oromucosal gel is useful in treating noise aversion in dogs. It is the first and only FDA-approved prescription formulated for this condition. It delivers a low dose of medication, allowing your dog to function and interact normally, but to also remain calm.
Key Benefits: Sileo works by blocking norepinephrine, a chemical within the brain that is known to accelerate anxiety (similar to adrenaline).
Formulated For: Intended for dogs 16 weeks of age and older.
How is Medication Given? Recommended Dosage Rates:
Dogs 4.4 to 12.1 Pounds: 0.25 mL Dogs 12.2 to 26.5 Pounds: 0.5 mL Dogs 26.6 to 44 Pounds: 0.75 mL Dogs 44.1 to 63.9 Pounds: 1 mL Dogs 64 to 86 Pounds: 1.25 mL Dogs 86.1 to 110.2 Pounds: 1.5 mL Dogs 110.3 to 137.8 Pounds: 1.75 mL Dogs 137.9 to 166.4 Pounds: 2 mL Dogs 166.5 to 196.2 Pounds: 2.25 mL Dogs 196.3 to 220.5 Pounds: 2.5 mL 1 mL contains 0.1 mg of Dexmedetomidine Hydrochloride. For doses larger than 1.5 mL, divide between both sides of mouth. Administer onto oral mucosa between the gum and cheek. Recommended dosage rate is 125 mcg/m2. This gel should be absorbed, not swallowed. Product may be ineffective if swallowed. If swallowed, wait 2 hours to re-dose. Administer the first dose when you detect a noise stimulus (like fireworks) that elicits fear or anxiety, right after your dog shows noise-related fear or anxiety symptoms, or about 30 to 60 minutes before an anxiety-causing stimulus. If the bothersome noise lasts more than 2 to 3 hours and anxiety or fear returns, administer another dose. Allow for 2 hours between doses, administering no more than 5 doses per event.
What Results Can I Expect? Sileo:
Works alone, requiring no training or other treatments Is easy to administer at home Calms dogs, but doesn't sedate them Acts rapidly to calm dogs, but lets the dog and their parent/family interact normally Is proven safe and effective through a placebo-controlled, random clinical trial Is an easy-to-administer treatment for noise aversion, which can be challenging for pets and their parents
What Form Does Medication Come In? Gel, Syringes
Dose and Administration: Sold as a syringe containing 3 mL (0.09 mg per mL).
Possible Side Effects: Rarely, adverse reactions have included:
Short-term mucous membrane paleness at the application site Vomiting (emesis) Drowsiness Sedation
Precautions Never use in a dog with:
Severe cardiovascular disease Respiratory disease Liver disease Kidney disease Conditions of shock or severe debilitation Conditions of stress associated with fatigue, extreme heat, or extreme cold Hypersensitivity to dexmedetomidine or any of the excipients Hypotension Hypoxia Bradycardia Never administer to a dog who was sedated with prior dosing. Not proven safe for use in dogs under the age of 16 weeks; dogs with dental or gingival disease (which may affect absorption); or in pregnant, breeding, or lactating dogs. Do not allow direct exposure to the skin, eyes, or mouth while handling or administering a filled syringe. Disposable, impermeable gloves should be worn to handle or administer, and when coming into contact with the dog's mouth after dosing. If you are pregnant, do not handle Sileo. Exposure can induce uterine contractions or cause decreased blood pressure in the fetus. Keep out of reach of children.
Storage Recommendations: Store syringes in original package at room temperature between 68-77 degrees F (20-25 degrees C). Brief excursions of 59-86 degrees F (15-30 degrees C) are permitted. Use contents of syringe within 2 weeks of opening.
In Case of Overdose: Contact the nearest emergency pet clinic immediately.
