For: Dogs (8 weeks of age and older)

Brand Name: Simparica Trio

Product Strength & Size: Weight RangeSarolaner (per tablet)Moxidectin (per tablet)Pyrantel (per tablet)2.8 to 5.5 lbs3 mg0.06 mg12.5 mg5.6 to 11 lbs6 mg0.12 mg25 mg11.1 to 22 lbs12 mg0.24 mg50 mg22.1 to 44 lbs24 mg0.48 mg100 mg44.1 to 88 lbs48 mg0.96 mg200 mg88.1 to 132 lbs72 mg1.44 mg300 mg*For dogs over 132 lbs, administer the appropriate combination of tablets to cover your pet's body weight.Usage*For complete Description, please review the full prescribing information in the manufacturer package insert.Simparica Trio should be given orally at monthly intervals year–round, or as otherwise directed by your veterinarian.Do NOT remove tablets from the foil blister pack until just before administration. The sealed blister pack should be kept in its original box⁄packaging for protection from environmental factors (e.g., light, moisture).Manufacturer Dosage and Administration:Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg⁄lb (1.2 mg⁄kg) sarolaner, 0.011 mg⁄lb (24 ÃÂ¼g⁄kg) moxidectin, and 2.27 mg⁄lb (5 mg⁄kg) pyrantel (as pamoate salt).Simparica Trio can be offered to the dog with or without food.Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.Missed dosesIf a dose is missed: give Simparica Trio immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once.If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.StorageStore in a cool, dry place at a controlled room temperature (at or below 86°F). Keep out of the reach of children and pets. Tablets should remain sealed in their original packaging and should only be taken out of the blister pack at the time of dosing. Store away from heat and direct sunlight.Do not store this medication in the bathroom, near the kitchen sink, or in damp places. The medicine may break down if exposed to heat or moisture.Side effectsSimparica Trio is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, and lowered energy level.Contact your veterinarian immediately if you notice your pet has a seizure, tremors, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking).Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome.If you notice anything unusual, please consult your veterinarian.Precautions*For complete Description including warnings and precautions, please refer to the manufacturer package insert.For oral use in dogs only– not for use in humans.Sarolaner is a member of the isoxazoline class.This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adultD. immitis.The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups.Do not administer to animals with a known history or suspected allergy⁄hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies.If your pet displays symptoms of an allergic reaction, discontinue therapy and call your veterinarian immediately or seek emergency veterinary attention. Symptoms may include (but are not limited to): swollen lips, tongue, face, or airways, difficulty breathing, agitation, profuse salivation, and widespread hives or itching.Drug and food interactionsThere are no documented drug or food interactions with Simparica Trio.*NOTE: this may not be a comprehensive list. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together.Please ensure your veterinarian is aware of all medications and supplements that your pet is currently receiving. Your veterinarian may prescribe multiple medications, even if a potential drug interaction may occur. In these instances, your veterinarian may adjust the dosages or monitor your pet more closely.Adverse reactionsIf you are concerned that your pet has experienced an adverse reaction to this medication, please contact the manufacturer Zoetis at 888–963–8471 or Vetsource Pet Owner Care at 877–738–4443.OverdoseIf you have any reason to suspect an overdose, call your doctor⁄veterinarian or the appropriate poison control resource immediately.For humans:The national toll–free Poison Help line, 1–800–222–1222, will connect you to your local poison center in case of emergency. This service is available nationwide and in most U.S. territories.For animals:The ASPCA Animal Poison Control Center is

Manufacturer: Zoetis

Active Ingredients: Sarolaner, Moxidectin, Pyrantel pamoate

Inactive Ingredients: Complete inactive ingredients list not provided by manufacturer.

Usage: *For complete Description, please review the full prescribing information in the manufacturer package insert. Simparica Trio should be given orally at monthly intervals year–round, or as otherwise directed by your veterinarian. Do NOT remove tablets from the foil blister pack until just before administration. The sealed blister pack should be kept in its original box⁄packaging for protection from environmental factors (e.g., light, moisture). Manufacturer Dosage and Administration: Simparica Trio is given orally once a month, at the recommended minimum dose of 0.54 mg⁄lb (1.2 mg⁄kg) sarolaner, 0.011 mg⁄lb (24 ÃÂ¼g⁄kg) moxidectin, and 2.27 mg⁄lb (5 mg⁄kg) pyrantel (as pamoate salt). Simparica Trio can be offered to the dog with or without food. Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused.

Precautions: *For complete Description including warnings and precautions, please refer to the manufacturer package insert. For oral use in dogs only– not for use in humans. Sarolaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Prior to administration of Simparica Trio, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. Simparica Trio is not effective against adultD. immitis. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Discuss the risks of using this medication with your veterinarian if your pet is in one of these groups. Do not administer to animals with a known history or suspected allergy⁄hypersensitivity to this medication or any of its ingredients. Allergic reactions to medications may occur. Be sure to inform Vetsource and your veterinarian if your pet has any known drug sensitivities or allergies. If you

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