Usage: *For complete product information, please review the full prescribing information in the manufacturer package insert. Trifexis should be given orally at monthly intervals year–round, or as otherwise directed by your veterinarian. Manufacturer Dosage and Administration: Trifexis is given orally, once a month at the minimum dosage of 13.5 mg⁄lb (30 mg⁄kg) spinosad and 0.2 mg⁄lb (0.5 mg⁄kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes. Administer Trifexis with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of Trifexis with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.

Missed Doses: If a dose is missed: give Trifexis immediately to resume monthly dosing and notify your veterinarian. Do not give two doses at once. If multiple doses have been missed, consult your veterinarian prior to restarting the monthly dosing schedule.

Side Effects: Trifexis is generally well tolerated, and side effects are considered uncommon when given at the recommended dosage. The most common side effects of this medication are vomiting, diarrhea, decreased appetite, excessive salivation⁄drooling, itching, skin reactions (e.g., dermatitis), trembling, lethargy, and skin or ear reddening. Contact your veterinarian immediately if your pet experiences a shock–like reaction, severe or persistent vomiting, or if you notice your pet has a seizure, extreme weakness, or decreased coordination (e.g., stumbling, difficulty walking). Notify your veterinarian if your pet experiences any of the effects described above, or if you notice any other side effects that are persistent or troublesome. If you