Empty and clean litter box before adding Nature's Miracle Litter Box Odor Destroyer. Sprinkle a layer of Nature's Miracle Litter Box Odor Destroyer on the bottom of the litter box. Then, fill litter box with litter. Once litter box is filled, sprinkle a second layer of powder on top of the litter box (about ¼ to ½ cup). Using waste scoop, blend the second layer of powder into the litter. Re-sprinkle: apply a thin layer of powder after each scooping or when new litter is added. Keep container closed when not in use.